Inhibiting quinolone biosynthesis of Burkholderia
نویسندگان
چکیده
منابع مشابه
Amino Acid Biosynthesis Inhibiting Herbicides
The identification of herbicide families that act through the inhibition of amino acid biosynthesis has resulted in revolutionary progress in agricultural practices. This review describes three herbicide classes which act through this mode-of-action; including glufosinate (also called phosphinothricin, Liberty, Ignite, or Finale) which inhibits ammonia assimilation, glyphosate (Roundup, Tou...
متن کاملEnzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis
Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively. Among enzyme-catalyzed epoxide transformations, a reaction that is notably missing, in regard to the synthetic toolbox, is cationic rearrangement that takes place under strong acid. This is a challenging transformation for enzyme catalysis, ...
متن کاملSources of Diversity in Bactobolin Biosynthesis by Burkholderia thailandensis E264
A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting anti...
متن کاملAspergillus oryzae produces compounds inhibiting cholesterol biosynthesis downstream of dihydrolanosterol.
The formation of cholesterol synthesis inhibiting molecules by five different strains of the koji mold Aspergillus oryzae was studied. After growing these strains on a complex liquid medium we found in crude organic phase extracts and specific fractions there from compounds inhibiting cholesterol synthesis in human hepatic T9A4 cells in vitro at enzyme sites downstream of dihydrolanosterol. Thi...
متن کاملSynthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa.
We explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to the active site zinc of elastase and additionally acts as a fluorescent zinc sensor.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Science
سال: 2021
ISSN: 2041-6520,2041-6539
DOI: 10.1039/d0sc06167k